By Stefan Guhlke (auth.), Jan Bucerius, Hojjat Ahmadzadehfar, Hans-Jürgen Biersack (eds.)
99mTc-sestamibi is a single-photon emission computed tomography (SPECT) radiotracer that's customary for the imaging of myocardial perfusion, in addition to a number of malignant and benign illnesses. 99mTc-Sestamibi – medical functions presents a close and informative evaluation of virtually all of the oncologic and non-oncologic purposes of 99mTc-sestamibi SPECT, together with numerous rather infrequent symptoms. diverse disease-related protocols for 99mTc-sestamibi SPECT are awarded, and for every ailment a finished precis of the proper pathology and epidemiology is supplied. all through, there's a powerful emphasis at the sensible elements of use of this renowned tracer, together with directions for the practise of a number of commercially on hand tracer kits. scientific practitioners will locate this e-book to be a useful consultant to the applying and advantages of 99mTc-sestamibi SPECT in either the inpatient and the outpatient setting.
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Additional info for 99mTc-Sestamibi: Clinical Applications
J Nucl Med 30:301–311 13. Leide S, Diemer H, Ahlgren L, et al (1992) In vivo distribution and dosimetry of Tc-99m MIBI in man. In: S-Stelson A, Watson EE (eds) Fifth International Radiopharmaceutical Dosimetry Symposium Conf-910529, Oak Ridge Asoociated Universities, Oak Ridge, TN, pp 483–497 24 M. Konijnenberg 14. Boström P-A, Diemer H, Leide S, Lilja B, Bergqvist D (1993) 99Tcm-Sestamibi uptake in the leg muscles and in the myocardium in patients with intermittent claudication. Angiology 44:971–976 15.
3 mg/dL had a positive scan as compared with 60% of those with lesser values. Similarly, a serum PTH level greater than 160 pg/mL correlated with positive scans in 93% as opposed to 57% in those with lower levels. Lower Ca and PTH levels thus seem to correlate with reduced sensitivity of Sestamibi. These ﬁndings were supported by a paper published by Hung et al.  who measured intact parathyroid hormone levels in hyperparathyroidism and correlated the data with Sestamibi imaging: visualization of hyperfunctioning parathyroid glands on 99mTc-parathyroid scintigraphy was more likely with the higher serum i-PTH level in a dose-dependent manner.
Published a survey on new trends in parathyroid scintigraphy : the authors concluded that parathyroid scintigraphy can be recommended not only in persistent or recurrent hyperparathyroidism, but also in hyperparathyroid patients prior to ﬁrst surgery. Especially since minimally invasive procedures requiring 4 Parathyroid Imaging 43 unilateral exploration of the neck have become popular, a new era of parathyroid scintigraphy has been opened: the preoperative proof of an adenoma can guide the surgeon to reduce operation time and invasiveness of the procedure.
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