July 16, 2017

Download Airway Mucus: Basic Mechanisms and Clinical Perspectives by John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. PDF

By John G. Widdicombe (auth.), Dr. Duncan F. Rogers, Dr. Michael I. Lethem (eds.)

Conceptually unsavoury, airway mucus is key to homeostasis within the breathing tract. against this, while irregular, mucus contributes considerably to the pathophysiology of a few serious bronchial illnesses, together with bronchial asthma, power bronchitis and cystic fibrosis. This quantity offers vast ranging and in-depth insurance of the medical and scientific facets of airway mucus. It commences with introductory chapters which deal with the biochemical and molecular organic foundation of airway mucus and maintains with entire assurance of many of the physiological and rheological features of breathing secretions. The scientific facets of the subject are then thought of, with chapters discussing the involvement of mucus secretions in bacterial an infection and in hypersecretory illnesses of the airway. the amount concludes with a dialogue of the healing features of the subject, either by way of the potential techniques to the remedy of mucus hypersecretion and the interplay of those medicines with airway mucus. Written by way of best specialists within the box, every one contribution offers a entire evaluate of its specific topic. Reflecting the newest advances during this vital sector of breathing examine, this quantity may be of significant curiosity to scientists and clinicians operating within the box of airway secretions and comparable areas.

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Extra resources for Airway Mucus: Basic Mechanisms and Clinical Perspectives

Sample text

T a ~ [ a ~ en (') s· 1g: ;I- 46 M. C. Rose and S. J. Gendler O-glycan core types may be biosynthetically elongated at serine and/or threonine residues in tandem repeat (TR) domains; a different core structure may be elongated in threonine/serine/proline-rich (TSP) domains; and yet a third core structure may be generated in cysteine-rich (CR) or other domains. Each MUC protein may exhibit a unique cell or tissue-specific O-glycosylation, and it may be altered by disease. For example, MUCI proteins isolated from human milk have core type-2 O-glycosides, while MUCI mucins from BT-20 breast cancer cells have core type-l O-glycosides [12].

2. Mucin Apoproteins Mucins are emerging as a large family of glycoproteins, and eDNA cloning has so far identified at least eight different human mucin genes [20-28]. Deduced amino acid sequences have confirmed the presence of STP-rich and cysteine-rich domains and highlighted some hitherto unexpected features of mucin apoprotein structure. For example, a characteristic feature of many, though not all, of the identified mucins is the repetitive nature of the glycan attachment STP-rich regions.

Thus, we would predict that the large heterogeneity of respiratory mucin oligosaccharides will even-tually be resolved into smaller subgroups associated with specific mucin gene products. The role of mucin oligo saccharides remains to be fully understood. It has been demonstrated that certain bacteria bind specific oligosaccharide ligands, and it has been speculated that the primary function of oligosaccharide diversity is to enhance the possibility that bacteria bind to mucus and, thus, facilitate their removal by mucociliary transport.

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