July 16, 2017

Download An update on glomerulopathies : clinical and treatment by Sharma S Prabhakar PDF

By Sharma S Prabhakar

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Lupus (2009) 18, 1091–1095 Nayagam L,Ganguli SA. Mycophenolate mofetil or standard therapy for membranous nephropathy and focal segmental glomerulosclerosis: a pilot study Nephrol Dial Transplant (2008) 23: 1926–1930 Pantelista K. Koutroulia E. Sotsiou F. , Oumenos DS: Benefit and cost from the long-term use of cyclosporine-A in idiopathic membranous nephropathy Nephrology 15 (2010) 762–767 Expert Opin. Pharmacothery. J Am Soc Nephrol 21: 697–704, 2010. Ponticelli C,Passerini P. J Nephrology 2010 ; 23 (02): 156-163 Ponticelli C.

A distinctive feature is the presence of dilated tubules forming microcysts that contain loose proteinaceous casts. This pattern can occur both in primary FSGS and also in secondary FSGS due to HIV,parvovirus B12,pamidronate toxicity and interferon therapy. Endothelial tubuloreticular inclusions are identified in over 90% of patients with HIVinfection collapsing glomerulopathy and interferon therapy, whereas only in 10% cases with idiopathic collapsing glomerulopathy. Besides these conditions endothelial tubuloreticular inclusions are seen commonly in systemic lupus erythematosus nephritis.

Treatment with eculizumab improves the quality of life and reduces the need of transfusions and the risk of thrombosis in patients with PNH. However, eculizumab can increase the risk of meningococcal infections perhaps due to the reduction in the levels of C5 activity. Patients should therefore be vaccinated or revaccinated with a meningococcal vaccine at least 2 weeks before receiving the first dose of eculizumab. Other side effects include headache, nasopharingitis, back pain and cough; nausea may occur in the period following injection.

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