By Zhifei Dai
This publication highlights the hot advances in nanotheranostics from simple study to strength purposes, and discusses the modular layout and engineering of multiplex nanoparticles together with gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. every one bankruptcy demonstrates multifunctional nanoparticles with subject matters protecting focusing on, imaging, supply, diagnostics, and treatment as new modalities for melanoma theranostics. This complete ebook offers specialist perspectives at the most up-to-date advancements in theranostic nanomedicine.
It specializes in capability theranostic functions of multifunctional nanoparticles starting from opting for noninvasively melanoma cells through molecular detection, and visualizing in vivo drug supply through distinction more suitable imaging, to destroying melanoma mobilephone s with minimum unwanted effects through selective accumulation at tumor websites, and real-time tracking healing effectiveness. It additionally offers an interdisciplinary survey of nanotheranostics and as such is a important source for researchers and scholars in similar fields.
Zhifei Dai is a Professor on the division of Biomedical Engineering, university of Engineering, Peking collage, China.
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Extra resources for Advances in Nanotheranostics I: Design and Fabrication of Theranosic Nanoparticles
1 Near-Infrared Light-Mediated Gold Nanoplatforms for Cancer Theranostics 31 Fig. 11 (a) TEM images of Au nanostars (GNSs). (b) UV-vis-NIR spectra of GNSs. (c) The generation of free radicals under irradiation determined by the SOSG ﬂuorescence intensity. (d, e) Temperature curves of different GNSs (d) and GNS-treated tumors (e) irradiated by laser over time. 0 W/cm2) for 6 min 32 L. Wang et al. was covalently anchored on the surface of Au nanostars. To induce both hyperthermia and PDT effect by a single NIR CW laser, they adapted the LSPR of Au nanostars to ﬁt that of Ce6.
The right indicates number of modulated proteins by AuNRs and the representative protein quantitative conﬁrmation using western blot analyses. (e) The effects of AuNRs on the migration and invasion abilities of cancer cells, using transwell migration and invasion assays. (f) Effects of AuNRs on the intracellular ATP level, using a luciferase-based luminescence assay that is normalized to protein concentrations. Before ATP measurement, the cells are pretreated with or without 100 mM 2-deoxyglucose (2-DG), 1 μM oligomycin (OM), or 50 μ M AuNRs for 24 h.
AuNCs were conjugated with [Nle4,D-Phe7] α-melanocyte-stimulating hormone (NDP-MSH), a peptide which selectively binds to the α-MSH receptors overexpressed on melanoma. The photoacoustic signal in the melanoma was much stronger for the NDP-MSH-conjugated AuNCs than that of nontargeted AuNCs, which demonstrated an enhanced uptake of AuNCs by the tumor due to active targeting. The initial study on the ability to destroy cancer cells in vitro by AuNCs-mediated photothermal effect was also demonstrated by Xia’s group [160, 161].
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