By Norman K. Hollenberg (auth.), Naranjan S. Dhalla Ph.D., M.D. (Hon.), Peter Zahradka Ph.D., Ian M. C. Dixon Ph.D., Robert E. Beamish M.D. (eds.)
The dating among angiotensin II and high blood pressure used to be confirmed in 1898 while angiotensin II was once proven to modulate systemic blood strain. Over the intervening many years, an entire characterization of the renin-angiotensin approach (RAS) has been accomplished, and our figuring out of its biochemistry and body structure has resulted in the directed improvement of brokers such ·as ACE inhibitors and receptor antagonists able to controlling high blood pressure. extra lately, it was once proven that angiotensin II is secreted inside definite tissues and that those tissue-specific platforms function independently of the systemic RAS. the unconventional idea that angiotensin II regulates a few cardiovascular strategies which are unrelated to blood strain has renewed the curiosity of either simple and scientific scientists in angiotensin II. The organization among angiotensin II and cardiac development, specifically, has indicated that cures at the moment in use for high blood pressure could have direct software to the remedy of middle failure. The Manitoba Cardiovascular discussion board on Angiotensin Receptor Blockade in Winnipeg used to be convened October 18-20, 1996 to ascertain the scientific and simple elements of angiotensin receptor biology as they observe to high blood pressure and center failure. furthermore, the capability therapy of those stipulations utilizing particular angio tensin receptor antagonists used to be addressed in the context in their rapid healing software and destiny potential.
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Additional info for Angiotensin II Receptor Blockade Physiological and Clinical Implications
Hypertension 9:384-389. 22. Hollenberg NK, Williams GH. 1995. Abnonnal renal function, sodium-volume homeostasis and renin system hypertension: The evolution of the nonmodulator concept. In Hypertension: Pathophysiology, diagnosis, and management, 2nd ed. Vol. 2. Edited by JH Laragh and BM Brenner, 1837-1856. New York: Raven Press. 23. Hopkins PN, Lifton RP, Hollenberg NK, Jeunemaitre X, Hallouin M-C, Skuppin J, Williams CS, Dluhy RG, Lalouel J-M, Williams RR, Williams GH. 1996. Blunted renovascular response to Ang II is associated with a common variant of the AGT gene and obesity.
With an exceptional intellect, enormous energy, and a talent for practicality, he cast a mantle over medicine, science, administration, research, philosophy, education, and business. He is a renaissance man in the age of molecular biology. Dr. Naimark was born and educated in Winnipeg. He achieved great distinction during his undergraduate studies, winning medals, scholarships and prizes. As an undergraduate he enrolled in a special program of research and study leading to the degree of Bachelor of Science in Medicine, which was awarded concurrently with the Doctor of Medicine degree in 1957.
Details of studies demonstrating the presence of RAS pep tides and enzymes in the brain have been extensively reviewed elsewhere [28,29]. The components of the brain RAS are distributed in areas that mediate cardiovascular regulation and body fluid homeostasis, including septal nuclei, the preoptic region, hypothalamic nuclei, the midbrain, and nuclei of the medulla oblongata . The presence of the brain RAS in other discrete regions such as the basal ganglia suggests a role in other functions.
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