July 16, 2017

Download Anticarbohydrate Antibodies: From Molecular Basis to by François-Xavier Theillet, Pierre Chassagne (auth.), Paul PDF

By François-Xavier Theillet, Pierre Chassagne (auth.), Paul Kosma, Sven Müller-Loennies (eds.)

Many pathogens and aberrant malignant cells show distinctive carbohydrates on their floor representing appealing ambitions for vaccine layout. enormous development has lately been made within the identity of novel carbohydrate dependent vaccines and a multitude has reached scientific part reports. The luck of a number of authorized carbohydrate established vaccines opposed to bacterial pathogens similar to Haemophilus influenzae kind b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their nice power. despite the fact that, the research of anti-carbohydrate antibodies is technically tough and in part due to low affinities and promiscuous specificity they've got no longer been medically exploited to complete capability. The research of antibody specificities and id of protecting carbohydrate epitopes lies on the middle of profitable vaccine layout. as well as remedy, antibodies often function diagnostic instruments in scientific and medical laboratories. during this atmosphere excessive affinity and beautiful specificity are vital elements for his or her winning use. “Anticarbohydrate Antibodies – from molecular foundation to medical program” compiles present wisdom at the immunological acceptance of carbohydrates through the adaptive immune method from a molecular point of view delivering basic perception wanted for advancing clinically suitable diagnostics and healing functions. in line with major development within the fields of glycoimmunology and structural biology in recent times, the booklet comprehensively stories the cutting-edge in defining the most important parts of carbohydrate popularity by way of antibodies, the molecular mimicry of carbohydrate epitopes in addition to the molecular positive aspects resulting in particular and secure binding modes. Backed-up through a mix of recent applied sciences to explain structural information of carbohydrate-antibody interactions, biomedically very important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells were analyzed in in-depth studies written through famous specialists within the box. basic wisdom of those molecular mechanisms finally offers a rational foundation to enhance efficacy of carbohydrate-based vaccines and to additional refine diagnostic instruments in detection of pathogens and malignant cells.

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Additional resources for Anticarbohydrate Antibodies: From Molecular Basis to Clinical Application

Sample text

In agreement with the observed differences in epitope size, LPS crossreactivities were at variance. In particular, MASF Y2, which accommodates epitopes larger than an octasaccharide had a specificity restricted to SFY. Overall, in addition to emphasizing the contributions of well-characterized OSs in probing the fine specificity of O-Ag:Ab complementarity, these findings revealed the complexity of the SFY O-Ag antigenic repertoire (Carlin et al. 1987b). They also substantiated the more recent understanding that Abs recognizing large epitopes were more likely to discriminate between different serotypes (Theillet et al.

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