By Dr. med., Prof. Herbert Begemann, Dr. med., Priv.-Doz. Johann Rastetter (auth.)
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Haemoglobinization is normal. 8. Punctate basophilia of erythrocytes. Basophil stippling is a sign of increased, but disordered regeneration. Especially frequently seen in lead poisoning. Normally there are 0-4 stippled cells per 10000 erythrocytes. 38 8 Fig. 9. Erythrocytes (continued) '" 1250 x 1. Sickle cells in constitutional sickle cell anaemia (drepanocytosis). This is similar to spherocytic anaemia and elliptocytosis a hereditary anomaly which predominates in negroes. But sickling is only rarely demonstrable in the usual blood smears.
Diabetes mellitus. 52 18 19 20 Fig. 21. Eosinophil and basophil granulocytes, toxic granulation of leucocytes, Pelger anomaly of the nucleus, anomalous granulation of Alder '" 1250 x Eosinophil granulocytes (cell 1-9) develop in the same way as the neutrophils. Beginning with the stage of myelocytes they are distinguishable with certainty. But typical eosinophil granulation is sometimes already encountered in promyelocytes and, according to Undritz, also in myeloblasts. The nuclear structure corresponds with that of the respective stages of the neutrophils.
The nucleus reveals a very delicate dense chromatin structure with several light blue nucleoli, up to 6, which as a rule are well delimited. e. the number of mitoses per 1000 myeloblasts, is however high. The chromosomes are of medium width. Fig. 11. Tissue basophils (tissue mast cells) '" 1250 x Two types of mast cells are distinguished according to size of nucleus, shape and density of granules. The nucleus of mastoblasts or promastocytes is relatively large, of indistinct structure and contains few granules.
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