July 16, 2017

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By Professor Dr. med. Helmut Löffler, Professor Dr. med. Johann Rastetter (auth.)

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Apparently they perform important tasks relating to nutrition and differentiation of the blood cell precursors. Two different types of reticulum cell are known to occur in the lymph nodes and spleen: the "dendritic reticulum cell," which occurs exclusively in germinal centers, primary follicles, and occasionally in the peripheral zones of follicles, and the "interdigitating reticulum cell," which is specific to the thymus-dependent region of the lymph node (see Fig. 132 for details). The "fibroblastic reticulum cell" described by Lennert and Miiller-Hermelink can occur in all regions of the lymph node as well as in bone marrow, but as yet it has not been positively identified by light microscopy.

4 a-d a b c d B Blood and Bone Marrow I 27 Fig. 4 e-f e f 28 I B Blood and Bone Marrow Fig. 5 a -f. Erythrocytes 1 The morphologic evaluation of erythrocytes is based on the following criteria: - Size - Shape - Hemoglobin: concentration, distribution - Stainability - Distribution in the smear - Inclusions a. Normal erythrocytes (diam. 7 - 8 ~m). b. Hypochromic erythrocytes in iron deficiency anemia. The cells, which have normal diameters, are conspicuous for their paucity of hemoglobin, which may form only a thin peripheral rim (anulocytes).

Right: At the center are three erythrocytes with numerous gray-violet granules that contain iron. This is a clear-cut pathologic finding that is rarely observed. i. Reticulocytes in various stages of maturity. The more filamentous reticula are characteristic of younger cells (brilliant cresyl blue stain, see p. 8) Fig. 6a-d a b c d B Blood and Bone Marrow I 33 Fig. 6 e-h • • e f g ,. ~ h 34 I B Blood and Bone Marrow Fig. , . B Blood and Bone Marrow I 35 Fig. 7 a-h. Myeloblasts and promyelocytes Myeloblasts are the earliest precursors of granulocytopoiesis that can be identified by light microscopy.

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